SS-31 (Elamipretide) is a synthetic peptide studied in laboratory research focused on mitochondrial biology, cardiolipin interactions, and cellular energy processes.
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SS-31 Product Overview SS-31, also known as Elamipretide or MTP-131, is a synthetic aromatic-cationic tetrapeptide studied for its interaction with mitochondrial membranes and cardiolipin-associated structures. Each vial contains 10mg of lyophilized SS-31 intended for controlled laboratory investigation of mitochondrial membrane biology, cardiolipin interactions, oxidative-phosphorylation pathways and cellular bioenergetics. Product Specifications Product name: SS-31 Alternative names: Elamipretide, MTP-131 and Bendavia Quantity per vial: 10mg Peptide length: 4 amino-acid residues Sequence: H-D-Arg-Dmt-Lys-Phe-NH2 Dmt designation: 2,6-dimethyltyrosine CAS number: 736992-21-5 Reference molecular formula: C32H49N9O5 Reference molecular weight: 639.8 g/mol as the free peptide Format: Lyophilized material Container: Single vial Structural Characteristics SS-31 contains alternating cationic and aromatic residues. Its structure includes D-arginine, the non-standard aromatic residue 2,6-dimethyltyrosine, lysine and a C-terminally amidated phenylalanine. These structural features have been investigated in relation to cellular uptake, peptide stability and interactions with lipid membranes. SS-31 does not use a conventional mitochondrial-targeting sequence and is studied for its association with components of the inner mitochondrial membrane. SS-31 and Cardiolipin Cardiolipin is a specialized phospholipid concentrated within the inner mitochondrial membrane. It contributes to membrane organization, mitochondrial cristae structure and the operation of proteins involved in oxidative phosphorylation. Biophysical, biochemical and mass-spectrometry studies have examined interactions between SS-31, cardiolipin-containing membranes and cardiolipin-associated mitochondrial proteins. Although SS-31 is frequently described as a selective cardiolipin-binding peptide, its membrane interactions are complex and may involve both lipid and protein environments. Results can vary according to membrane composition, experimental model and analytical method. Scientific Background Research involving SS-31 has examined mitochondrial membrane organization, electron-transport-chain activity, oxidative phosphorylation, ATP-related processes and reactive oxygen species within cellular and animal models. Published studies have also identified interactions between SS-31 and mitochondrial proteins associated with ATP production and 2-oxoglutarate metabolism. These findings provide research hypotheses concerning mitochondrial bioenergetics but should not be presented as guaranteed effects of this Nuforme material. References to mitochondrial protection, improved energy production or reduced oxidative stress describe experimental observations from specific models. They do not establish equivalent performance in every research system. Potential Research Areas Cardiolipin-binding and membrane-interaction studies Inner mitochondrial membrane models Mitochondrial cristae structure Electron-transport-chain research Oxidative-phosphorylation pathways ATP-production assays Reactive oxygen species measurements Mitochondrial protein-interaction mapping Peptide stability and degradation Analytical identity and purity testing SS-31 and Pharmaceutical Elamipretide Elamipretide is also the active compound used in a regulated pharmaceutical product. That product contains elamipretide hydrochloride in a defined aqueous formulation with specified excipients, concentration, manufacturing controls and regulatory requirements. The Nuforme SS-31 10mg research vial is a separate research material. Information involving the regulated pharmaceutical formulation does not independently confirm the identity, purity, sterility, safety or performance of this product. No pharmaceutical equivalence should be claimed or implied. Research involving this material must rely on the specifications and analytical documentation associated with its individual batch. Analytical Considerations Researchers should review the batch-specific Certificate of Analysis for peptide identity, HPLC purity, measured content, molecular-mass confirmation, counterion or salt form, batch number and analysis date. The reference molecular weight of 639.8 g/mol applies to the free peptide. Hydrochloride, acetate or trifluoroacetate forms have different formulas and total molecular weights. The salt or counterion associated with the supplied material should therefore be confirmed in the batch documentation. HPLC purity, mass-spectrometry identity and total vial quantity represent different analytical measurements. A purity percentage does not independently confirm that the vial contains the stated 10mg quantity. Storage Store the unopened vial according to the conditions stated on the product label and batch-specific documentation. Keep the material sealed and protected from light, heat and moisture. Storage instructions for a pharmaceutical elamipretide formulation should not be applied to this lyophilized research material. For laboratory research only. Not for human consumption or veterinary use. This product is not a drug, medication, supplement or cosmetic and is not intended to diagnose, treat, cure or prevent any disease. No dosing, administration or reconstitution instructions are provided.
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